Carlos A Guzmán Selected Research

cyclic diadenosine phosphate

1/2020	Mucosal Heterologous Prime/Boost Vaccination Induces Polyfunctional Systemic Immunity, Improving Protection Against Trypanosoma cruzi.
1/2019	The STING activator c-di-AMP exerts superior adjuvant properties than the formulation poly(I:C)/CpG after subcutaneous vaccination with soluble protein antigen or DEC-205-mediated antigen targeting to dendritic cells.
1/2017	Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against Trypanosoma cruzi.
1/2017	Mucosal Administration of Cycle-Di-Nucleotide-Adjuvanted Virosomes Efficiently Induces Protection against Influenza H5N1 in Mice.
1/2017	Cyclic dinucleotides modulate induced type I IFN responses in innate immune cells by degradation of STING.
1/2017	Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection.
1/2014	Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellular immune responses and provides protection against virus challenge.

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Carlos A Guzmán Research Topics

Disease

22	Infections 07/2021 - 04/2003
15	Human Influenza (Influenza) 02/2021 - 07/2006
5	Bites and Stings (Sting) 01/2020 - 01/2017
5	Chagas Disease (American Trypanosomiasis) 01/2017 - 01/2008
4	Neoplasms (Cancer) 07/2019 - 08/2007
4	Communicable Diseases (Infectious Diseases) 01/2019 - 06/2010
3	Acquired Immunodeficiency Syndrome (AIDS) 08/2008 - 06/2003
2	Virus Diseases (Viral Diseases) 01/2017 - 03/2006
2	Inflammation (Inflammations) 01/2017 - 12/2012
1	Thrombocytopenia (Thrombopenia) 10/2020
1	Persistent Infection 01/2020
1	Parasitic Diseases (Parasitic Disease) 01/2020
1	Hypertension (High Blood Pressure) 07/2019
1	Herpes Zoster 07/2019
1	Myocardial Infarction 07/2019
1	Pneumonia (Pneumonitis) 01/2019
1	Bacterial Infections (Bacterial Infection) 01/2019
1	Bacteremia 01/2019
1	Tetanus 01/2019
1	Diphtheria 01/2019
1	Pneumococcal Infections 01/2019
1	Weight Loss (Weight Reduction) 01/2017
1	Parasitemia 01/2017
1	Breast Neoplasms (Breast Cancer) 01/2016
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2016
1	Cardiomyopathies (Cardiomyopathy) 03/2015
1	Hepatitis B 12/2013
1	Hemolysis 11/2013
1	Influenza in Birds (Avian Flu) 11/2013
1	Eosinophilia 12/2012
1	Chronic Hepatitis C 05/2010
1	Carcinoma (Carcinomatosis) 05/2008
1	Carcinogenesis 05/2008
1	Hypersensitivity (Allergy) 01/2008

Drug/Important Bio-Agent (IBA)

24	VaccinesIBA 07/2021 - 06/2003
8	AntigensIBA 07/2019 - 04/2007
7	cyclic diadenosine phosphateIBA 01/2020 - 01/2014
7	Proteins (Proteins, Gene)FDA Link 01/2019 - 12/2003
4	Influenza Vaccines (Influenza Vaccine)FDA Link 06/2020 - 05/2014
4	Adenosine Monophosphate (AMP)IBA 01/2019 - 01/2014
3	Hemagglutinins (Hemagglutinin)IBA 07/2021 - 07/2006
3	Peptides (Polypeptides)IBA 07/2021 - 08/2006
3	CytokinesIBA 01/2019 - 04/2014
3	EnzymesIBA 03/2015 - 01/2008
3	cruzipainIBA 03/2015 - 04/2008
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2019 - 12/2012
2	LigandsIBA 01/2019 - 05/2010
2	Antiviral Agents (Antivirals)IBA 01/2018 - 01/2016
2	InterferonsIBA 01/2018 - 01/2017
2	OligodeoxyribonucleotidesIBA 01/2017 - 05/2008
2	Immunoglobulin G (IgG)IBA 01/2017 - 01/2008
2	bis(3',5')-cyclic diguanylic acidIBA 05/2014 - 11/2013
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2014 - 05/2010
2	macrophage stimulatory lipopeptide 2IBA 04/2008 - 06/2006
2	AntibodiesIBA 04/2007 - 06/2006
1	Biological ProductsIBA 02/2021
1	Biomarkers (Surrogate Marker)IBA 06/2020
1	SaltsIBA 01/2019
1	AluminumIBA 01/2019
1	Poly I-CIBA 01/2019
1	aluminum sulfate (alum)IBA 01/2019
1	Interleukin-6 (Interleukin 6)IBA 01/2019
1	Toll-Like Receptor 7IBA 01/2018
1	vesicular stomatitis virus G proteinIBA 01/2017
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2017
1	Galactosylceramides (Galactocerebrosides)IBA 01/2017
1	NucleotidesIBA 01/2017
1	Interleukin-17 (Interleukin 17)IBA 01/2017
1	Subunit VaccinesIBA 01/2017
1	VirosomesIBA 01/2017
1	Histocompatibility Antigens Class IIBA 12/2016
1	Papillomavirus Vaccines (HPV Vaccines)IBA 01/2016
1	Cysteine Proteases (Cysteine Protease)IBA 03/2015
1	DNA VaccinesIBA 03/2015
1	Guanosine Monophosphate (5' Guanylic Acid)IBA 05/2014
1	Silicon Dioxide (Silica)FDA LinkGeneric 05/2014
1	Interferon-betaIBA 04/2014
1	NucleoproteinsIBA 01/2014
1	Biosimilar PharmaceuticalsIBA 12/2013
1	Hepatitis B Surface Antigens (HBsAg)FDA Link 12/2013
1	ChitosanIBA 11/2013
1	Toll-Like Receptor AgonistsIBA 12/2012
1	OvalbuminIBA 12/2012
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 12/2012
1	AllergensIBA 12/2012
1	Pharmaceutical PreparationsIBA 01/2012
1	Peptide Hydrolases (Proteases)FDA Link 07/2010
1	Interferon-alpha (Interferon Alfa)IBA 05/2010
1	Ribavirin (Virazole)FDA LinkGeneric 05/2010
1	RNA (Ribonucleic Acid)IBA 05/2010
1	Interleukin-2 (IL2)IBA 01/2008
1	Interferon-gamma (Interferon, gamma)IBA 01/2008
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2008
1	Creatine Kinase (Creatine Phosphokinase)IBA 01/2008
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2008
1	alpha-galactosylceramideIBA 08/2007

Therapy/Procedure

3	Therapeutics 01/2019 - 05/2010
2	Mucosal Administration 01/2017 - 12/2012
1	Platelet Transfusion (Blood Platelet Transfusions) 10/2020
1	Injections 05/2008